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Cystic Fibrosis And Infertility
Dec 2017
Dr Priti Gupta
Consultant Fertility and IVF, First Step IVF Clinic

Cystic fibrosis is a genetic disorder that affects various parts of the body, mainly the lungs, pancreas, intestines, liver and kidneys. The disease is caused by a mutation in the gene which is responsible for affecting a protein that regulates the movement of salt in the cells. In complicated cases, individuals with cystic fibrosis may have bronchiectasis, chronic Infections, nasal polyps, hemoptysis, pneumothorax and even infertility, especially in males.

Infertility And Cystic Fibrosis (CF)
Approximately 97 per cent men with cystic fibrosis are infertile. However, many medical researchers have found that these men are not sterile and can have children through assisted reproductive techniques such as IVF, Intracytoplasmic Sperm Injection (ICSI) and Cryopreservation.

The reason for infertility among men with cystic fibrosis is the congenital absence of vas deferens. Other factors as a result of CF are zero/low sperm count, abnormally shaped sperms, or poor motility of the sperm. On the other hand, females with CF have thick cervical mucus which disrupts the process of ovulation, resulting in the lack of menstruation.

The Symptoms
Depending on the severity of the disease, the symptoms of cystic fibrosis may vary. However, an individual can have variant symptoms which may get worse over a period of time. Nevertheless, to detect the disease, doctors count on the following symptoms are